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KMID : 0615720140310020065
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Jouranl of Korean Acupuncture and Moxibustion society
2014 Volume.31 No. 2 p.65 ~ p.74
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The Effect of Hoelen Herbal-acupuncture at KI10 on Lipopolysaccharide Induced Nephritis in Rats
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Kim Min-Sik
Kim Byung-Soo
Yim Yun-Kyoung
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Abstract
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Objectives: The purpose of this study is evaluating the effect of Hoelen Herbal-acupuncture (HO-HA) at KI10(Umgok) on Lipopolysaccharide(LPS) induced nephritis in rats
Methods: The experimental rats were assigned to four groups; normal, LPS, saline, HO-HA groups. LPS(2 mg/kg) was administered to the rats in LPS, saline and HO-HA groups to induce acute inflammatory kidney damage. Saline injection and HO-HA were administered at KI10 three times a week.
Blood samples were taken from the rats for analysis of white blood cell(WBC), neutrophil, blood urea nitrogen(BUN), creatinine TNF-α, CINC-1. Urine samples were taken from the rats for analysis of urinal volume, creatinine and total protein. The kidney samples were taken from the rats for analysis of renal myeloperoxIdase(MPO).
Results: HO-HA suppressed the increases of WBC and neutrophils in blood, BUN, creatinine, TNF-α and CINC-1 in serum, and MPO in kidney of LPS-stimulated rats. In addition, HO-HA inhibited the decrease of urinary volume in LPS-stimulated rats.
Conclusions: HO-HA has therapeutic effects on LPS-induced inflammatory kidney damage in rats. Further studies may be needed for clinical use of HO-HA.
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KEYWORD
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Herbal-acupuncture, Nephritis, LPS, KI10, Hoelen
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